Estudio de la rigidez arterial en arteria carótida y depósito tisular de hierro mediante resonancia magnéticarelación con los factores de riesgo asociados al síndrome metabólico
- Blasco Solã, Gerard
- Wifredo Ricart Angel Doktorvater/Doktormutter
- Simone Balocco Doktorvater/Doktormutter
- José Manuel Fernández Real Lemos Doktorvater/Doktormutter
Universität der Verteidigung: Universitat de Girona
Fecha de defensa: 21 von Mai von 2015
- José María Alústiza Echeverría Präsident
- Joan Vendrell Ortega Sekretär/in
- Tomás Alarcón Cor Vocal
Art: Dissertation
Zusammenfassung
The aim is to demonstrate the utility of magnetic resonance (MR) for identifying subclinical changes associated with the metabolic syndrome (MS) that contribute to increased cardiometabolic risk. The effect of MS on arterial stiffness and tissue iron load were evaluated using MR in subjects with the MS and control subjects. Arterial stiffness was higher in subjects with MS than in those without. The components contributing independently to an increased pulse wave velocity were hypertension and hypertriglyceridemia. Increased iron concentration was significantly detected at the liver and brain in obese subjects. Obesity-associated brain iron overload was correlated with worse cognitive performance. Obesity and insulin resistance were found as the main factors that contribute to tissue iron deposition. In conclusion, this thesis demonstrates the utility of MR to evaluate subclinical risk changes associated with the MS in subjects without diabetes or ischemic disease