Enfermedad inflamatoria intestinalpapel del análisis molecular de los virus de la familia herpes sobre material tisular

Résumé

Viruses of the herpes family of human affect humans ubiquitously making questionable its pathogenetic role in certain diseases demonstrated despite its presence. Moreover, the difficulty in interpreting laboratory techniques available for detecting and reach an accurate diagnosis prevents in most cases early detection of infection and effective treatment. There are cases of inflammatory bowel disease in which is described using different diagnostic methods for the presence of virus, although the actual role of the viral presence in tissue in the course of the disease is far from clear. Therefore, since it has been shown that there is a percentage of cases of inflammatory bowel disease which can identify viral particles, the tissue of these patients apparently shows no changes in viral infection by conventional morphological methods and unable to determine the clinical evolution of these patients, our working hypothesis is to study the biopsy material of patients with inflammatory bowel disease and apply techniques of molecular pathology (PCR and quantitative real-time PCR), correlate viral load in the tissue with the evolution the patient and the response to different therapeutic and try to describe morphological lesions that may correlate with the presence of such viruses by molecular tests.