The role of osteopontin in liver fibrosis

  1. SYN, WING KIN
unter der Leitung von:
  1. Patricia Aspichueta Celaa Doktormutter

Universität der Verteidigung: Universidad del País Vasco - Euskal Herriko Unibertsitatea

Fecha de defensa: 19 von September von 2017

Gericht:
  1. Begoña Ochoa Olascoaga Präsident/in
  2. Mª Luz Martínez Chantar Sekretär/in
  3. Shishir R. Shetty Vocal

Art: Dissertation

Teseo: 143830 DIALNET lock_openADDI editor

Zusammenfassung

Osteopontin (OPN) is a cytokine and matrix molecule that is upregulated in human and mouse models of chronic liver injury and directly promotes liver fibrogenesis by activating hepatic stellate cells (HSC) and liver progenitors (LPC). OPN is secreted by multiple cell types including HSC, LPC, as well as recruited immune cells such as natural killer T (NKT) cells, which amplify the fibrogenic response. In vivo, OPN neutralization abrogates the LPC response, inhibits HSC activation, and reduces liver fibrosis, thus demonstrating that targeting OPN is a potentially attractive anti-fibrotic strategy.