Functional and structural characterization of peptides derived from hiv-1 gp41 membrane proximal and transmembrane domains. Implications for anti-hiv inhibitor and inmunogen development
- Jose Luis Nieva Escandón Directeur/trice
Université de défendre: Universidad del País Vasco - Euskal Herriko Unibertsitatea
Fecha de defensa: 11 juin 2012
- Jesús Pérez Gil President
- Francesc Xabier Contreras Gómez Secrétaire
- Enrique Pérez Payá Rapporteur
- Jamie K. Scott Rapporteur
- Gorka Basañez Asua Rapporteur
Type: Thèses
Résumé
1- Relevant in vitro assays for MPER membrane activity should include:- MPER peptide redefined to bear the hydrophobic-at-interface region plus the Nterminalresidues of the TMD.- A lipid bilayer whose composition includes concentrations of cholesterol as highas those present in the viral envelope.2- Preliminary results support that in vitro assays for MPER activity, optimizedaccording to those parameters, are useful tools for new HIV-1 inhibitor and immunogendevelopment.