Effects of social stress on tumor development in dominant male mice with diverse behavioral activity profiles

  1. Cacho Fernández, Raúl
  2. Garmendia Rezola, Larraitz
  3. Vegas Moreno, Óscar
  4. Azpiroz Sánchez, Arantza
Revista:
Psicothema

ISSN: 0214-9915

Año de publicación: 2008

Volumen: 20

Número: 4

Páginas: 818-824

Tipo: Artículo

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Otras publicaciones en: Psicothema

Resumen

Efectos del estrés social en el desarrollo tumoral de ratones macho dominantes con diferentes perfiles de actividad conductual. Se examinó la influencia del perfil psicológico individual y del comportamiento social en el desarrollo tumoral de ratones macho dominantes. Los animales fueron sometidos a un test de campo abierto (OFT) para medir la actividad locomotora y la latencia. Posteriormente, los animales se dividieron en tres grupos: Stress-No-Inoculado (SNI), Stress-Inoculado (SI) y Control-Inoculado (CI). SI y CI fueron inoculados con células tumorales y SNI con vehículo. Los grupos SI y CI fueron sometidos a estrés mediante la interacción con un animal intruso anósmico, seis (T1) y veintiún (T2) días después de la inoculación y analizada su conducta. Finalmente los animales fueron sacrificados y se contaron las metastásis pulmonares. SI desarrolló más metástasis que CI, indicando un efecto del estrés a pesar de su estatus de ganador. Los animales activos desarrollaron menos metástasis que los pasivos. Aunque no se encontraron diferencias conductuales a T1, sí se encontraron diferencias a T2 entre SI y SNI, y entre activos y pasivos. Estas diferencias indican que existe un efecto del desarrollo tumoral en la conducta social que es más evidente en los sujetos pasivos.

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Fuente de los datos: Dialnet