p53, un gen supresor tumoral

  1. M. López 1
  2. M. Anzola 1
  3. N. Cuevas-Salazar 1
  4. J. M. Aguirre 1
  5. M. Martínez de Pancorbo 1
  1. 1 Universidad del País Vasco/Euskal Herriko Unibertsitatea
    info

    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España

    ROR https://ror.org/000xsnr85

Journal:
Gaceta médica de Bilbao: Revista oficial de la Academia de Ciencias Médicas de Bilbao. Información para profesionales sanitarios

ISSN: 0304-4858,  2173-2302

Year of publication: 2001

Volume: 98

Issue: 1

Pages: 21-27

Type: Article

DOI: 10.1016/S0304-4858(01)74350-8 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Gaceta médica de Bilbao: Revista oficial de la Academia de Ciencias Médicas de Bilbao. Información para profesionales sanitarios

Sustainable development goals

Abstract

Tumor suppressor genes are involved in several processes of cell division such as, transcriptional regulation, cell cycle control, programmed cell death and genome stability. Loss of activity of these genes causes the inability of response to the mechanisms of control that regulate cell division, so that an uncontrolled cell proliferation is caused which sometimes leads to the development of neoplasias. p53 tumor suppressor gene is a multifactorial factor able to control cell cycle progression, DNA integrity and survival of the cells exposed to DNA damaging agents. p53 gene alteration confers a high risk of developing cancer and its mutation is one of the most frequent genetic changes in human neoplasia.

Data source: Dialnet