Haplotipos del intron 1 del receptor estrogénico, pico de masa ósea y riesgo de fracturas osteoporóticas
- J. A. Riancho
- María Teresa Zarrabeitia Cimiano
- Ricardo Franco Vicario
- Jesús González Macías
ISSN: 1132-8460
Datum der Publikation: 2002
Ausgabe: 11
Nummer: 1
Seiten: 13-15
Art: Artikel
Andere Publikationen in: Revista Española de Enfermedades Metabólicas Oseas
Zusammenfassung
Several studies about the relationship between estrogen receptor polymorphisms and bone mass have given conflicting results. It has recently been reported that haplotypic analysis is more discriminant than the allelic one. The aim of this study was to determine the relationship between Px haplotype and bone mass and fractures in our female population. A region in intron 1 of estrogen receptor alpha was amplified by PCR and digested with enzymes Pvull and Xbal. We did not find an association between bone mineral density of young women (i.e., peak bone mass) and the presence or the absence of Px haoplotype. However, this haplotype was more common in women with hip fracture than in control women (odds ratio 2.7; CI 95% 1.1-6.9; p = 0.03). These results suggest that the presence of Px haplotype may be related to postmenopausal bone loss rather than peak bone mass.