Compuestos orgánicos persistentes y metales pesados en sangre y efectos en el desarrollo neuropsicológico de la primera infancia en las cohortes de madres-niños INMA (infancia y medio ambiente)

  1. Aritz Aranbarri Paredes 1
  2. Eduardo Fano Ardanaz 1
  3. Sabrina Llop Pérez
  4. Rosa Ramón Bonache
  5. Mario Murcia Hinarejos
  6. Mònica Guxens Junyent
  7. Nerea Lertxundi Iribar 1
  8. Jesús Ibarluzea Maurolagoitia
  1. 1 Universidad del País Vasco/Euskal Herriko Unibertsitatea
    info

    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España

    ROR https://ror.org/000xsnr85

Journal:
Revista de Salud Ambiental

ISSN: 1697-2791

Year of publication: 2012

Volume: 12

Issue: 1

Pages: 3-13

Type: Article

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Abstract

Introduction: The INMA project is a multicenter study based on prospective monitoring of mother-child cohorts in different Spanish geographical areas. Objective: To study the relationship between major environmental pollutants and child development in the pre-and postnatal phases. Material and Methods: The cohort groups share data collection methodology and tools (environmental exposure, biological samples, physical and neuropsychological examinations, diet questionnaires etc.) during intrauterine growth and monitored childhood development. Results: The levels of Persistent Organic Pollutants (POPs) in serum during the first trimester of pregnancy are reported, together with those for lead (Pb) and total mercury (Hg-T) in the umbilical cord, which are associated with the neuropsychological development analyzed to date. The POPs most frequently found were p, p’-DDE (99%) and PCB 153 (95%) with geometric mean in serum (ng / g-lipid) of 110.0 (p, p’-DDE) and 38.9 (PCB 153). The geometric mean and the maximum Pb level were 1.06 mg/dL and 19 mg/dL, respectively. The geometric mean Hg-T was 8.2 mg/L, with fish consumption being the main predictor. The Hg-T reference levels set by USEPA (6.4 mg/L) were exceeded in 64% of the samples. Conclusion: T The levels of POPs and Pb observed in the study areas were within the range of values previously described in earlier studies. The Hg levels require more in-depth assessment, as well as study of the possible associations with neuropsychological development

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