Metabolismo hepático de estrógenos. Formación de compuestos intermedios reactivos y consecuencias tóxica
- Ruiz Larrea, M.B.
- Lacort Garrigosa, M.
ISSN: 0212-7113
Year of publication: 1992
Volume: 9
Issue: 1
Pages: 10-14
Type: Article
More publications in: Revista de toxicología
Abstract
The hepatic metabolism of estrogens and its subsequent toxic effects are here briefly reviewed. Estrogenic chemicals are oxidativelymetabolized in both the cytosolic and microsomal hepatic compartments. In the endoplasmic reticulum estrogens are hydroxilated by a NADPH-dependent cytochrome P450 linked monooxigenase system. Catecholestrogens are, thus, produced and can be further converted into reactive quiñones and semiquinones. These and other derivatives have been proposed to play a critical role in the development of lethal alterations of cell structure and function produced by chronic estrogen treatments. The involvement of these reactive intermediates in toxic alterations of hepatic me tabolism, including changes in the normal redox balance, thioldepletion and Ca2+ homeostasis, hasbeenpoorly investigated and is considered in this review