Hidrogeles de gelatina entrecruzados para aplicaciones en Ingeniería Tisular. Un estudio preliminar.

  1. Chato-Astrain, J
  2. Durand-Herrera, D
  3. García-García, O
  4. Sánchez-Porras, D
  5. Díaz-Ramos, M
  6. Albadalejo-García, V
  7. Irastorza-Lorenzo, A
  8. Campos, F
  9. Garzón, I
Journal:
Actualidad médica

ISSN: 0365-7965

Year of publication: 2018

Tome: 103

Issue: 803

Pages: 9-12

Type: Article

DOI: 10.15568/AM.2018.803.OR02 DIALNET GOOGLE SCHOLAR lock_openDIGIBUG editor

More publications in: Actualidad médica

Abstract

Biomaterials play a key role in the development of new tissue substitutes as they provide the essential 3D environment to promote cell adhesion, migration and proliferation. In this sense natural biomaterials offer biologically active molecules which typically promote excellent cells adhesion and growth. Gelatin is a biomaterial whose high collagen content and its interbranching 3D network could certainly contribute to the construction of more native-like tissues. In this context, different techniques of chemical cross-linking have been used in order to improve the physical and mechanical properties of biomaterials for use in Tissue Engineering. Glutaraldehyde (GA) is a well-known chemical crosslinker that can provide materials with substantial improvement in tensile properties. The aim of this article is to test different GA concentrations to crosslink gelatin hydrogels to evaluate the potential application of these new crosslinked biomaterials according to the specific properties of the different tissues in the translational clinic. In this regard interesting findings were obtained that could be helpful to design controlled-properties scaffolds regarding its crosslinked degree that would facilitate the production of more suitable tissue-like products. The proposed 5% GA crosslinked gelatin hydrogels shown morphological patterns and meet the requirements of a first macroscopic and microscopic evaluation which suggests a potential application for the regeneration of cardiovascular tissue.

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