Cirrosis alcohólica, osteoporosis y marcadores del metabolismo óseo
- Escalante, M.
- Franco, R.
- Cubas, L.
- Goiría, J.I.
- Zulueta, M.L.
- Cabarcos, A.
- Duque, C.
- Miguel, F.
ISSN: 0304-4858, 2173-2302
Year of publication: 2003
Volume: 100
Issue: 3
Pages: 81-85
Type: Article
More publications in: Gaceta médica de Bilbao: Revista oficial de la Academia de Ciencias Médicas de Bilbao. Información para profesionales sanitarios
Sustainable development goals
Abstract
OBJECTIVES: 1) To know if there is a predominant type of osteoporosis in these patients (decreased bone formation or increased bone reabsorption). 2) To correlate this disease with different bone markers.SUBJECTS AND METHODS: Study population: 52 alcoholic cirrhotic males from 45 to 65 years old,with normal values of kidney function, nor-sedentary and without any treatment that could alterate the study.Design and variables: transversal descriptive study. The following variables were evaluated: bone disease (thoracic and lumbar spine standard X rays and bone densitometry (dual energy X-ray absorptiometry DPX plus LUNAR-DEXA, metabolic bone markers (osteocalcin, 25-hydroxyvitamin D, urine calcium, creatinine, hydroxyproline and deoxypyridinoline, serum tartrate resistant acid phosphatase, intact PTH, free testosterone and estradiol) and laboratory examination.Statistical analysis: Macintosh computer (program Filemaker- PRO).RESULTS: osteopenia was considered if bone mineral density (BMD) was higher than 1 standard deviation (SD) but lower than 3 SD and osteoporosis (OP) if BMD was higher than 3 SD below T score (mean values for adult women) or there were spinal compression fractures. The total prevalence of bone disease (osteopenia and OP) was 58%. The bone loss appeared above all in lumbar spine (80%). High PTH and decreased magnesium and D vitamin revealed an alterated D vitamin metabolism. The osteodystrophy in alcoholic cirrhosis is due to an increase in bone reabsorption.