Modulación de las cinasas dependientes de ciclinas como nueva estrategia terapéutica

  1. Lertxundi, U.
  2. Corcóstegui, B.
  3. Peral, J.
  4. Ibarra, O.
  5. Martinez, MJ.
Journal:
Gaceta médica de Bilbao: Revista oficial de la Academia de Ciencias Médicas de Bilbao. Información para profesionales sanitarios

ISSN: 0304-4858,  2173-2302

Year of publication: 2005

Volume: 102

Issue: 2

Pages: 31-39

Type: Article

DOI: 10.1016/S0304-4858(05)74494-2 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Gaceta médica de Bilbao: Revista oficial de la Academia de Ciencias Médicas de Bilbao. Información para profesionales sanitarios

Sustainable development goals

Abstract

Hyperactivation of the key regulators of the cell cycle, the cyclin dependent kinases(CDKs), occurs in many human neoplasms. Therefore, modulation of these proteins mayhave an important use for cancer therapy and prevention.Flavopiridol and UCN-01 are the first compounds to enter clinical trials. Although resultshaven’t been as good as expected so far, combination with classic chemoterapic agentsand the development of more selective agents will probably produce better results.Key words: cyclin, kinase, therapy, cancer.

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