Impacto de las complicaciones postoperatorias en el pronóstico del cáncer gástrico

  1. Perfecto Valero, A. 1
  2. Serrano Hermosilla, C. 1
  3. Villalabeitia Ateca, I. 1
  4. Pérez Fernández, S. 2
  5. Zallo Gómez, L. 3
  6. Sarriugarte Lasarte, A. 3
  1. 1 Hospital Universitario Cruces. Servicio de Cirugía General y del Aparato Digestivo
  2. 2 Instituto de Investigación Sanitaria Biocruces Bizkaia
    info

    Instituto de Investigación Sanitaria Biocruces Bizkaia

    Barakaldo, España

    ROR https://ror.org/0061s4v88

  3. 3 Universidad del País Vasco/Euskal Herriko Unibertsitatea
    info

    Universidad del País Vasco/Euskal Herriko Unibertsitatea

    Lejona, España

    ROR https://ror.org/000xsnr85

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Journal:
Revista española de investigaciones quirúrgicas

ISSN: 1139-8264

Year of publication: 2022

Volume: 25

Issue: 2

Pages: 39-45

Type: Article

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More publications in: Revista española de investigaciones quirúrgicas

Abstract

Introduction. Surgery is the cornerstone in curative treatment of gastric cancer with complication rates ranging from 18% to 55%. The aim of the study was to analyze the impact of postoperative complications on overall survival (OS) of gastric cancer. Methods. This is a retrospective study of a single-center series. Patients who underwent curative gastrectomy between January 2010 and December 2014 were included. The severity of postoperative complications was studied according to the Clavien-Dindo classification. Patients OS was estimated using the method of Kaplan-Meier. Besides, univariate and multivariate analysis of the factors influencing on OS was performed. Results. 200 patients were included. Postoperative morbidity was 47.5%, with incidence rates of mild complications (CD II) of 24.5% and moderate-serious complications (CD III-IV) of 22.5%. The multivariate analysis of OS showed that postoperative complications significantly affected mortality (HR 1.61 [1.09, 2.42], p = 0.018). Medical compli-cations had an impact on OS (HR 1.89 [1.20; 2.96], p = 0.006), but surgical complications could not be statistically related (HR 1.49 [0.92; 2.43], p = 0.108). Conclusion. The present study shows the negative impact of postoperative medical complications on the overall survival of curative gastrectomy in patients with gastric cancer.

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