El perfil neuropsicológico en la esclerosis múltiple

  1. Arango Lasprilla, Juan Carlos
  2. Deluca, John
  3. Chiaravalloti, Giuseppe
Zeitschrift:
Psicothema

ISSN: 0214-9915

Datum der Publikation: 2007

Ausgabe: 19

Nummer: 1

Seiten: 1-6

Art: Artikel

Andere Publikationen in: Psicothema

Zusammenfassung

La Esclerosis Múltiple (EM) es la enfermedad neurológica no traumática más común entre personas jóvenes y adultos en etapas medias de la vida. La presente investigación tuvo como objetivo estudiar el perfil neuropsicológico de un grupo de sujetos con EM. A ochenta sujetos con diagnóstico de EM y 40 sujetos sanos se les administró una batería de evaluación neuropsicológica. El grupo de personas con EM presentó puntuaciones más bajas en todas las pruebas y, en el 84% de las variables medidas (16/19), las diferencias fueron estadísticamente significativas (p<0.05). El perfil neuropsicológico del grupo de sujetos con EM se caracterizó por alteraciones cognitivas en funciones ejecutivas, procesamiento de la información, memoria, habilidades visoespaciales y atención. Las alteraciones cognitivas son uno de los principales síntomas de la EM. El conocer el perfil neuropsicológico de estas personas es de gran relevancia tanto para el diagnóstico como para su posterior rehabilitación. Neuropsychological profile of multiple sclerosis. Multiple Sclerosis (MS) is the most common non-traumatic neurological disorder among young and middle-aged people. The aim of the present study was to examine the cognitive functioning of a group of MS patients. A sample of 80 participants diagnosed with MS and 40 controls received a comprehensive neuropsychological battery. Participants with MS scored lower than controls on all of the neuropsychological tests and significantly lower (p < .05) on 84% (16/19) of them. The global neuropsychological profile of the MS group included deficits in executive function, speed of information processing, memory, visuo-spatial abilities and attention. Cognitive deficits are one of the main symptoms of MS. Recognition of these deficits is relevant both to the diagnosis and rehabilitation of this disorder.

Bibliographische Referenzen

  • Amato, M.P., Ponziani, G., Pracucci, G., Bracco, L., Siracusa, G., y Amaducci, L. (1995). Cognitive impairment in early-onset multiple sclerosis. Pattern, predictors and impact on everyday life in a 4-year followup. Archives of Neurology, 52, 168-72.
  • Arango-Lasprilla, J.C., Rogers, H., Lengenfelder, J., DeLuca, J., Moreno, S., y Lopera, F. (2006). Cortical and subcortical diseases: Do true neuropsychological differences exist? Archives of Clinical Neuropsychology, 21, 29-40.
  • Arnett, P.A. (2004). Speed of presentation influences story recall in college students and persons with multiple sclerosis. Archives of Clinical Neuropsychology, 19, 507-23.
  • Arnett, P.A., Rao, S.M., Bernardin, L., Grafman, J., Yetkin, F.Z., y Lobeck, L. (1994). Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis. Neurology, 44, 420-5.
  • Arnett, P.A., Rao, S.M., Grafman, J., Bernardin, L., Luchetta, T., Binder, J.R., y Lobeck, L. (1997). Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding and planning abilities. Neuropsychology, 11, 535-44.
  • Barbizet, J., & Cany, E. (1968). Clinical and psychometrical study of a patient with memory disturbances. International Journal of Neurology, 7, 44-54.
  • Beatty, P.A., y Gange, J.J. (1977). Neuropsychological aspects of multiple sclerosis. Journal of Nervous and Mental Disease, 164, 42-50.
  • Beatty, W.W. (1993). Memory and «frontal lobe» dysfunction in multiple sclerosis. Journal of the Neurological Sciences, 115, 38-41.
  • Beatty, W.W., y Monson, N. (1989). Lexical processing in Parkinson’s disease and multiple sclerosis. Journal of Geriatrics and Psychiatry Neurology, 2, 145-52.
  • Beatty, W.W., y Monson, N. (1996). Problem solving by patients with multiple sclerosis: Comparison of performance on the Wisconsin and California Card Sorting Tests. Journal of International Neuropsychological Society, 2: 134-40.
  • Benton, A.L., Sivan, A.B., y Hamsher, K. (1994). Contributions to neuropsychological assessment. A clinical manual (2nd ed). New York: Oxford University Press.
  • Boringa, J.B., Lazeron, R.H., Reuling, I.E., Ader, H.J., Pfennings, L., Lindeboom, J., et al. (2001). The brief repeatable battery of neuropsychological tests: Normative values allow application in multiple sclerosis clinical practice. Multiple Sclerosis, 7, 263-7.
  • Buschke, H., y Fuld, P.A. (1974). Evaluating storage, retention and retrieval in disordered memory and learning. Neurology, 24, 1019-25.
  • DeLuca, J., Barbieri-Berger, S., y Johnson, S.K. (1994). The nature of memory impairments in multiple sclerosis: Acquisition versus retrieval. Journal of Clinical and Experimental Neuropsychology, 16, 183-9.
  • DeLuca, J., Chelune, G.J., Tulsky, D.S., Lengenfelder, J., y Chiaravalloti, N.D. (2004). Is speed of processing or working memory the primary information processing deficit in multiple sclerosis? Journal of Clinical and Experimental Neuropsychology, 26, 550-62.
  • DeLuca, J., Gaudino, E.A., Diamond, B.J., Christodoulou, C., y Engel, R.A. (1998). Acquisition and storage deficits in multiple sclerosis. Journal of Clinical and Experimental Neuropsychology, 20, 376-90.
  • De Sonneville, L.M.J., Borninga, J.B., Reiling, I.E.W., Lazeron, R.H.C., Ader, H.J., y Polman, C.H. (2002). Information processing characteristics in subtypes of multiple sclerosis. Neuropsychologia, 40, 1751-65.
  • Drake, M.A., Allegri, R.F., y Carra, A. (2002). Language abnormalities in patients with multiple sclerosis. Neurologia, 17, 12-6.
  • Feinstein, A. (2004). The neuropsychiatry of multiple sclerosis. Canadian Journal of Psychiatry, 49, 157-63.
  • Foley, F., LaRocca, N., Sandres, A., y Zemon, V. (2001). Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis. Multiple Sclerosis, 7, 417-21.
  • Foong, J., Rozewicz, L., Quaghebeur, G., Davie, C.A., Kartsounis, L.D., Thompson., A.J., et al. (1997). Executive function in multiple sclerosis. The role of frontal lobe pathology. Brain, 120, 15-26.
  • Friend, K.B., Rabin, B.M., Groninger, L., Deluty, R.H., Bever, C., y Grattan, L. (1999). Language function in patients with multiple sclerosis. The Clinical Neuropsychology, 13, 78-94.
  • Golden, C.J. (1978). Stroop Color and Word Test. Chicago, IL: Stoelting. Heaton, R., Chelune, G., Talley, J., Kay, G., y Curtiss, G. (1993). Wisconsin Card Sorting Test Manual. Odessa, Florida: Psychological Assessment Resources.
  • Janculjak, D., Mubrin, Z., Brinar, V., y Spilich, G. (2002). Changes of attention and memory in a group of patients with multiple sclerosis. Clinical Neurology and Neurosurgery, 104, 221-7.
  • Jansen, D.A., y Cimprich, B. (1994). Attentional impairment in persons with multiple sclerosis. Journal of Neuroscience Nursing, 26, 95-102.
  • Krupp, L.B., Álvarez, L.A., LaRocca, N.G., y Sheinberg, L.C. (1998). Fatigue in multiple sclerosis. Archives of Neurology, 45, 435-7.
  • Krupp, L.B., Sliwinski, M., Masur, D.M., Friedberg, F., y Coyle, P.K. (1994). Cognitive functioning and depression in patients with chronic fatigue syndrome and multiple sclerosis. Archives of Neurology, 51, 705-10.
  • Kujala, P., Portin, R., Revonsou, A., y Ruutianen, J. (1995). Attention related performance in two cognitively different subgroups of patients with multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry, 59, 77-82.
  • Leary, S.M., y Thompson, A.J. (2000). Current management of multiple sclerosis. International Journal of Clinical Practice, 54, 161-9.
  • Paul, R.H., Beatty, W.W., Schneider, R., Blanco, C., y Hames, K. (1998). Impairments of attention in individuals with multiple sclerosis. Multiple Sclerosis, 4, 433-9.
  • Rao, S.M. (2004). Cognitive function in patients with multiple sclerosis: Impairment and treatment. Int MS Care, 1, 9-22.
  • Rao, S.M. (1986). Neuropsychology of multiple sclerosis: A critical review. Journal of Clinical and Experimental Neuropsychology, 8, 503- 42.
  • Santiago, O., Guardia, R., y Arbizu, T. (2006). Neuropsicología de los pacientes con esclerosis múltiple remitente recurrente con discapacidad leve. Psicothema, 18(1), 84-87.
  • Sanz de la Torre, J.C., y Pérez-Ríos, M. (2000). Neuropsychological evaluation in a case of multiple sclerosis. Revista de Neurología, 30, 1.161-5.
  • Shallice, T. (1982). Specific impairments of planning. Phil Trans R Soc Lond; 298, 199-209.
  • Simone, I.L., Carrara, D., Tortorella, C., Ceccarelli, A., y Livrea, P. (2000). Early onset multiple sclerosis. Neurological Sciences, 21, 861-3.
  • Smith, A. (1982). Symbol Digit Modalities Test Manual. Los Angeles, CA: Western Psychological Services.
  • Spreen, O., y Strauss, E. (1998). A compendium of neuropsychological tests: Administration, norms and commentary. New York: Oxford University Press.
  • Swirsky-Sacchetti, T., Mitchell, D.R., Seward, J., Gonzales, C., Lubin, F., Knobler, R., et al. (1992). Neuropsychological and structural brain lesions in multiple sclerosis: a regional analysis. Neurology, 42, 1291-5.
  • Thompson, A. (2001). Symptomatic management and rehabilitation in multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry, 71, 22-27.
  • Tinnefeld, M., Treitz, F.H., Haase, C.G., Wilhelm, H., Daum, I., y Faustmann, P.M. (2005). Attention and memory dysfunctions in mild multiple sclerosis. European Archives of Psychiatry and Clinical Neuroscience, 255(5), 319-326.
  • Uccelli, M.M., Mohr, L.M., Battaglia, M.A., Zagami, P., y Mohr, D.C. (2004). Peer support groups in multiple sclerosis: Current effectiveness and future directions. Multiple Sclerosis, 10, 80-4.
  • Vleugels, L., Christophe, L., Nunen, A., Charlier, M., Ketealer, P., y Vandenbussche, E. (2001). Visuoperceptual impairment in MS patients: Nature and possible neural origins. Multiple Sclerosis, 7, 389-401.
  • Vleugels, L., Christophe, L., Nunen, A., Nachtergaele, S., Ketealer, P., Charlier, M., y Vandenbussche, E. (2000). Visuoperceptual impairment in multiple sclerosis patients diagnosed with neuropsychological task. Multiple Sclerosis, 6, 241-54.
  • Wechsler, D. (1997). Wechsler Adult Intelligences Scale-third edition. San Antonio, TX:The psychological corporation.
  • Wechsler, D. (1987). Wechsler Memory Scale-Revised Manual. New York: Psychological Corporation.
  • Wilkinson, G.S. (1993). Wide Range Achievement Test-3 Administration Manual. Wilmington DE: Wide Range, Inc.
  • Zakzanis, K. (2000). Distinc neurocognitive profiles in multiple sclerosis subtypes. Archives of Clinical Neuropsychology, 15, 115-36.