Olanzapina y consumo de cocaína en programa de mantenimiento con metadona
- M.A. Landabaso 1
- I. Iraurgi 2
- J.M. Jiménez-Lerma 3
- J. Sanz 1
- R. Calle 1
- A. Larrazabal 4
- A. Aizpuru 1
- M. Gutiérrez 5
- 1 Centro de Drogodependencias Barakaldo
- 2 MAPS Rekalde. Bilbao
- 3 CTT Álava
- 4 CSM Rentería. Guipúzcoa
- 5 Hospital de Cruces. Barakaldo
ISSN: 1134-5934
Año de publicación: 2001
Volumen: 8
Número: 5
Páginas: 171-174
Tipo: Artículo
Otras publicaciones en: Psiquiatría biológica: Publicación oficial de la Sociedad Española de Psiquiatría Biológica
Resumen
Aims: Treatment with olanzapine was evaluated in 27 patients with repeated cocaine consumption without psychotic symptomatology on a methadone program. Patients and methods: Patients were selected from those who presented recurrent positive cocaine urine analysis over a 6-month period. Patients who consented to inclusion in the study received olanzapine 10 mg/d of for the following 6 months. Results: A very significant decrease in positive cocaine and heroin urine analysis was observed (cocaine 36.73% versus 2.38%; heroin 16.60% versus 4.35%). Likewise, a decrease was found in the mean dose of methadone between the previous 6 months and the 6 months on olanzapin. Five of the 27 patients withdrew from the study. Discussion: Olanzapine administration may favor compliance with the methadone program allowing a reduction in the daily dose of methadone and an important decrease in the consumption of cocaine and/or heroin.