Aportación del uso medicinal de los derivados del cannabisuna revisión de su potencial eficacia clínica y riesgos

Abstract

The use of cannabis derivatives as therapeutic agents raises today a broad scientific and social debate. There are some synthetic cannabis derivatives approved by drug regulatory agencies with clinical indications such as nausea and vomiting in cancer patients, or pain treatment among the most important. The objective of the work is the review, based on current scientific knowledge, of the potential therapeutic use, in terms of clinical efficacy and safety, of cannabis derivatives in different clinical situations, especially associated with the treatment of pain, basic treatment and / or coadjuvant in cancerous processes, as well as treatment of neurological and psychiatric diseases. For all these areas, at the present time, clinical research on the use of natural or synthetic cannabis derivatives is scarce, so it is recommended to promote it with controlled clinical studies according to the regulations of international drug regulatory agencies. It should be studies that, in addition to providing knowledge on the efficacy and safety of these products, demonstrate the most effective form of administration for therapeutic use, the most appropriate active components (Delta-9-tetrahydrocannabinol, cannabidiol), and the clinical impact of its association with other drugs. In conclusion, only the increase in scientific knowledge of the therapeutic properties of cannabis derivatives can help their legalization for medicinal purposes.