Research and development of advanced controlled drug delivery systemsapplication in Keratoconus and Leber´s Hereditary Optic Neuropathy

  1. Varela Fernández, Rubén
Dirigée par:
  1. Francisco Javier Otero Espinar Directeur/trice
  2. Isabel Lema Gesto Directeur/trice
  3. Miguel González Barcia Directeur/trice

Université de défendre: Universidade de Santiago de Compostela

Fecha de defensa: 27 juin 2022

Jury:
  1. José Blanco Méndez President
  2. Arantxa Acera Osa Secrétaire
  3. Alicia C. López Castellano Rapporteur

Type: Thèses

Teseo: 733876 DIALNET lock_openMINERVA editor

Résumé

In the present thesis, the research, development, and characterization processes of controlled drug delivery systems intended for the treatment of two different ocular pathologies were described. Firstly, different types of lactoferrin-loaded nanoparticles intended for topical ophthalmic administration were developed and proposed as the first pharmacological alternative for the Keratoconus (KC) treatment. On the other hand, idebenone-loaded polymeric implants and microparticles were designed and proposed as new therapeutic strategies for the treatment of Leber's Hereditary Optic Neuropathy (LHON).