Effects of maternal binge alcohol consumption on emotional, cognitive and addictive behaviour in mice

  1. Cantacorps Centellas, Lídia
Dirigida por:
  1. Olga Valverde Granados Director/a

Universidad de defensa: Universitat Pompeu Fabra

Fecha de defensa: 15 de noviembre de 2019

Tribunal:
  1. Nagore Puente Bustinza Presidente/a
  2. María Pascual Mora Secretario/a
  3. Ainhoa Bilbao Leis Vocal

Tipo: Tesis

Teseo: 608572 DIALNET

Resumen

Maternal alcohol binge drinking during pregnancy can be deleterious for the developing foetus, leading to a wide range of long-lasting morphological and neurobehavioural disabilities known as foetal alcohol spectrum disorders, associated with a higher risk of developing substance use disorders later in life. We sought to assess the effects of prenatal and postnatal alcohol exposure on cognitive, emotional, motor and addictive behaviour in mice and its underlying molecular mechanisms. Pregnant C57BL/6 female mice underwent a procedure to model alcohol binge drinking either during gestation or throughout both the gestation and lactation periods. Then, male offspring were assessed for their behaviour at adulthood. Binge alcohol exposure during early brain development induces cognitive deficits, increased anxiety-like behaviour, motor coordination impairments, and age-dependent locomotor activity alterations. Behavioural effects are associated with an upregulation of pro-inflammatory signalling, gliosis, neuronal death, myelin impairments and epigenetic modifications in the prefrontal cortex and hippocampus. Furthermore, early alcohol exposed mice show alterations in brain network connectivity. Curcumin treatment ameliorates anxiety and cognitive dysfunctions, and rescues alcohol-induced neuroinflammation. In addition, mice exposed to alcohol in utero and postnatally show increased susceptibility to later alcohol and cocaine intake compared with their counterparts. Molecular analyses of the prefrontal cortex and striatum of these animals suggest alterations in the glutamatergic excitability within the mesocorticolimbic reward system following cocaine-induced reinstatement. Altogether, our results reveal that maternal binge-like alcohol consumption induces molecular alterations in offspring’s brain that may underlie the long-lasting impairments in offspring’s behaviour.