SAT0622 High dose intravenous methylprednisolone induces rapid improvement in severe uveitis: a multicenter study of 129 patients

  1. Vegas-Revenga, N. 1
  2. Calvo-Río, V. 1
  3. González-Mazón, I. 1
  4. Sánchez-Bilbao, L. 1
  5. Beltrán, E. 2
  6. Follonosa, A. 3
  7. Maíz, O. 4
  8. Blanco, A. 4
  9. Cordero, M. 5
  10. Ortego, N. 6
  11. Torre, I. 7
  12. Hernández, F. 8
  13. Muñoz, S. 9
  14. Esteban, M. 9
  15. Diaz-Llopis, M. 10
  16. Cañal, J. 1
  17. Ventosa, J.A. 1
  18. Demetrio, R. 1
  19. Agudo, M. 1
  20. Dominguez-Casas, L. 1
  21. González-Gay, M.A. 1
  22. Blanco, R. 1
  1. 1 Hospital Universitario Marqués de Valdecilla
    info

    Hospital Universitario Marqués de Valdecilla

    Santander, España

    ROR https://ror.org/01w4yqf75

  2. 2 Hospital Universitario Doctor Peset
    info

    Hospital Universitario Doctor Peset

    Valencia, España

    ROR https://ror.org/03971n288

  3. 3 Hospital de Cruces
    info

    Hospital de Cruces

    Barakaldo, España

    ROR https://ror.org/03nzegx43

  4. 4 Hospital Universitario de Donostia
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    Hospital Universitario de Donostia

    San Sebastián, España

    ROR https://ror.org/04fkwzm96

  5. 5 H. de León, León
  6. 6 Hospital Universitario San Cecilio
    info

    Hospital Universitario San Cecilio

    Granada, España

  7. 7 Hospital Universitario de Basurto
    info

    Hospital Universitario de Basurto

    Bilbao, España

    ROR https://ror.org/00j4pze04

  8. 8 Hospital de Gran Canaria Dr. Negrin
    info

    Hospital de Gran Canaria Dr. Negrin

    Las Palmas de Gran Canaria, España

    ROR https://ror.org/00s4vhs88

  9. 9 Hospital Infanta Sofia
    info

    Hospital Infanta Sofia

    Madrid, España

    ROR https://ror.org/05dfzd836

  10. 10 Hospital Universitario La Fe
    info

    Hospital Universitario La Fe

    Valencia, España

    ROR https://ror.org/01ar2v535

Revista:
Annals of the Rheumatic Diseases

ISSN: 1468-2060 0003-4967

Año de publicación: 2018

Volumen: 77

Páginas: 1162-1163

Tipo: Artículo

DOI: 10.1136/ANNRHEUMDIS-2018-EULAR.3780 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Annals of the Rheumatic Diseases

Objetivos de desarrollo sostenible

Resumen

Background In uveitis rapid and effective remission-inducing therapy is mandatory to avoid irreversible damage.Objectives To evaluate the efficacy and safety of high-dose intravenous methylprednisolone (IVMP) pulse therapy in uveitis.Methods Multicentre study of 129 patients (203 eyes) with uveitis who received IVMP. The underlying diseases were: Idiopathic (n=30), Vogt Koyanagy Harada,29 Behçet disease,19 Sarcoidosis,6 Multifocal Choroidopathy,4 Birdshot chorioretinopathy,2 Acute posterior multifocal placoid pigment epitheliopathy,1 Granulomatosis with polyangiitis,2 Aortitis,1 Immune thrombocytopenic purpura,1 Rheumatoid arthritis,2 Axial Spondylitis,6 Psoriatic arthritis,2 Juvenile Idiopathic Arthritis,1 Thrombophilia synd.,1 Eales Disease,2 Sympathetic Ophthalmia,2 Multiple Sclerosis,2 Relapsing Polychondritis,1 Cogan’s synd.,1 Sjögren synd.,2 Crohn’s disease,1 Reactive arthritis,1 Toxic oil synd. and brain ischemia,1 Raynaud’s Disease and brain ischemia,1 Pseudotumor,1 Cataract surgery,1 Herpes Simplex,1 Varicella Zoster-associated acute retinal necrosis,1 T.pallidum3 and M.tuberculosis.1 The inflammatory ocular patterns were: panuveitis (66), posterior uveitis (PU),31 intermediate uveitis (IU),5 anterior uveitis (AU),12 AU and PU,2 AU and IU,1 IU and PU,1 exudative retinal detachment,3 vasculitis,4 pseudotumor,1 scleritis2 and sclero-uveitis.1 Bilateral ocular involvement was observed in 74 cases. Patients were assessed at basal visit and day 2–5, 7, 15 and 30 after IVMP. The main outcome variable was best corrected visual acuity (BCVA), the degree of inflammation of the anterior chamber and vitreous, and macular thickness (macular oedema defined by OCT >300 µm). The results are expressed as mean ±SD for normally distributed variables, or as median [interquartile range] when are not. Comparison of continuous variables was performed using the Wilcoxon test.Results We studied 74 &x2640;/55 &x2642;; mean age 42±14.3 years. IVMP dose ranged from 40–1000 mg/day for 3–5 consecutive days. Prior to IVMP, cycloplegic and corticosteroid eye drops were used in all cases. Improvement was faster among patients with inflammation in anterior chamber and vitritis than in BCVA, CME, retinitis and retinal vasculitis (TABLE). Total remission was achieved in 19.4% of the 129 patients after IVMP. In 126 of the patients continued with oral corticosteroids and 4 received an intraocular dose of steroids. These immunosuppressive drugs were added: Methotrexate (52), Cyclosporine A,48 Azathioprine40 and others.5 In a few cases biological therapy (64) was administered afterwards. In general, acute respiratory infection was the side-effect most frequent.Conclusions High-dose IVMP pulse therapy is beneficial in the prompt control of severe uveitis and it is well tolerated.