AB0771 High Dose Intravenous Methylprednisolone Induces Rapid Improvement of Visual Acuity in Non-Infectious Uveitis of Different Immune Mediated Inflammatory Diseases

  1. Vegas-Revenga, N. 1
  2. Martín-Varillas, J. L. 2
  3. Calvo-Río, V. 3
  4. González-Mazón, I. 3
  5. Sanchez-Bilbao, L. 3
  6. Beltrán, E. 4
  7. Fonollosa, A. 5
  8. Maiz-Alonso, O. 6
  9. Blanco, A. 36
  10. Cordero-Coma, M. 7
  11. Ortego, N. 8
  12. Torre-Salaberri, I. 9
  13. Francisco, F. 10
  14. Muñoz Fernandez, S. 11
  15. Esteban-Ortega, M. D. M. 11
  16. Díaz-Llopis, M. 12
  17. Cañal, J. 13
  18. Ventosa, J. A. 13
  19. Demetrio-Pablo, R. 13
  20. Domínguez, L. 14
  21. Agudo-Bilbao, M. 3
  22. Castañeda, S. 15
  23. Ferraz-Amaro, I. 16
  24. González-Gay, M. A. 3
  25. Blanco, R. 3
  1. 1 Hospital de Galdakao - Usansolo
    info

    Hospital de Galdakao - Usansolo

    Galdácano, España

    ROR https://ror.org/025714n80

  2. 2 Hospital Sierrallana
    info

    Hospital Sierrallana

    Torrelavega, España

    ROR https://ror.org/01b2c5015

  3. 3 Hospital Universitario Marqués de Valdecilla, Rheumatology, Santander, Spain
  4. 4 Hospital Universitario Doctor Peset
    info

    Hospital Universitario Doctor Peset

    Valencia, España

    ROR https://ror.org/03971n288

  5. 5 Hospital de Cruces
    info

    Hospital de Cruces

    Barakaldo, España

    ROR https://ror.org/03nzegx43

  6. 6 Hospital Universitario de Donostia
    info

    Hospital Universitario de Donostia

    San Sebastián, España

    ROR https://ror.org/04fkwzm96

  7. 7 Complejo Asistencial Universitario de León
    info

    Complejo Asistencial Universitario de León

    León, España

    ROR https://ror.org/05gn84d31

  8. 8 Hospital Universitario San Cecilio
    info

    Hospital Universitario San Cecilio

    Granada, España

  9. 9 Hospital Universitario de Basurto
    info

    Hospital Universitario de Basurto

    Bilbao, España

    ROR https://ror.org/00j4pze04

  10. 10 Hospital de Gran Canaria Dr. Negrin
    info

    Hospital de Gran Canaria Dr. Negrin

    Las Palmas de Gran Canaria, España

    ROR https://ror.org/00s4vhs88

  11. 11 Hospital Infanta Sofia
    info

    Hospital Infanta Sofia

    Madrid, España

    ROR https://ror.org/05dfzd836

  12. 12 Hospital Universitario La Fe
    info

    Hospital Universitario La Fe

    Valencia, España

    ROR https://ror.org/01ar2v535

  13. 13 Hospital Universitario Marqués de Valdecilla
    info

    Hospital Universitario Marqués de Valdecilla

    Santander, España

    ROR https://ror.org/01w4yqf75

  14. 14 Hospital San Agustin
    info

    Hospital San Agustin

    Avilés, España

    ROR https://ror.org/003zecf96

  15. 15 Hospital Universitario de la Princesa
    info

    Hospital Universitario de la Princesa

    Madrid, España

    ROR https://ror.org/03cg5md32

  16. 16 Hospital Universitario de Canarias
    info

    Hospital Universitario de Canarias

    San Cristóbal de La Laguna, España

    ROR https://ror.org/05qndj312

Mostrar afiliaciones +
Revista:
Annals of the Rheumatic Diseases

ISSN: 0003-4967,  1468-2060

Año de publicación: 2021

Volumen: 80

Número: Suppl 1

Páginas: 1412.1-1412

Tipo: Artículo

DOI: 10.1136/ANNRHEUMDIS-2021-EULAR.2159 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Annals of the Rheumatic Diseases

Objetivos de desarrollo sostenible

Resumen

Background: Rapid and effective remission-inducing therapy is mandatory in uveitis to avoid irreversible structural and functional damage. In some severe cases biological agents might be required (1-6).High-dose intravenous methylprednisolone (IVMP) may achieve prompt control of inflammation in most immune mediated inflammatory diseases (IMID), including non-infectious uveitis (NIU).Objectives: To evaluate the efficacy and safety of IVMP pulse therapy in NIU of different IMID.Methods: Multicentre study of 71 patients with severe uveitis who received IVMP. The underlying diseases were: Vogt Koyanagy Harada disease (VKHD) (n=24), Behçet disease (BD) (19), Sarcoidosis (5) and idiopathic NIU (23). The main outcome variable was Best-Corrected Visual Acuity (BCVA) estimated using the Snellen chart. BCVA that was assessed at 0 (basal), 2-5, 7, 15 and 30 days after IVMP.The results are expressed as mean ±SD in normally distributed variables, or as median [IQR] when are not. Comparison of continuous variables was performed using the Wilcoxon test.Results: We studied 46♀/ 25♂ patients. The main features are shown in Table 1. IVMP dose ranged from 250 to 1000 mg/day administered for 3-5 consecutive days, the dose was established according to the presence or not of other systemic manifestations apart from uveitis. All of them had active intraocular inflammation at the moment of the study. BCVA values improved considerably after 1 month (Figure 1). No major side effects were observed.Conclusion: High-dose IVMP pulse therapy is useful and safe for a prompt control of BCVA regardless of the underlying IMID.

Referencias bibliográficas

  • [1]Vegas-Revenga N, et al. Am J Ophthalmol. 2019; 200:85-94. doi: 10.1016/j.ajo.2018.12.019
  • [2]Calvo-Río V, et al. Clin Exp Rheumatol. 2014;32(4 Suppl 84): S54-7. PMID: 25005576
  • [3]Santos-Gómez M, et al. Clin Exp Rheumatol. 2016;34(6 Suppl 102): S34-S40. PMID:27054359
  • [4]Atienza-Mateo B, et al. Rheumatology (Oxford) 2018;57(5):856-864. doi: 10.1093/rheumatology/kex480.
  • [5]Atienza-Mateo B, et al. Arthritis Rheumatol. 2019; 71(12):2081-2089. doi: 10.1002/art.41026.
  • [6]Martín-Varillas JL, et al. Ophthalmology. 2018;125(9):1444-1451. doi: 10.1016/j.ophtha.2018.02.020