Morfinak hipometilazio globala eragiten du mES zeluletan autoerregulazioa daukan demetilazio aktibo baten bidez
- Manu Araolaza Lasa
- Iraia Muñoa Hoyos
- Ainize Odriozola Larrañaga
- Irune Calzado López
- Malen Zabala Goikoetxea
- Nerea Subiran Ciudad
- Olatz Arbelaitz Gallego (ed. lit.)
- Ainhoa Latatu (ed. lit.)
- Elixabete Pérez Gaztelu (ed. lit.)
Publisher: Udako Euskal Unibertsitatea, UEU = Universidad Vasca de Verano
ISBN: 978-84-8438-862-3, 978-84-8438-866-1
Year of publication: 2023
Pages: 167-174
Congress: Ikergazte. Nazioarteko Ikerketa Euskaraz (5. 2023. Donostia)
Type: Conference paper
Abstract
Environmental factors cause health problems and/or disease, but how it occurs is unknown. Most of the research carried out so Jar has indicated that epigenetic transformations can play a key role in this process, being the point of connection between both. Morphine, for example, can easily cross the placenta, which significantly ajfects the normal development of the embryo, ajfecting the development of the neur al tube, frontal cortex and spinal cord, making it difficult for the proper development of the nervous system. Therefore, considering that DNA methylation is a key epigenetic transformation in embryonic development, our objective is to clarify the role that methylation can play in the presence of morphine, for which we have resorted to state-of the-art techniques.