Epe luzerako ondorioak loki-lobuluko epilepsia sagu-eredu baten garunean
- Garazi Ocerin Amondarain 1
- Ilazki Anaut Lusar
- Amaia Mimenza Saiz
- Leire Lekunberri
- Maitane Serrano Murgia
- Edgar Soria-Gómez
- Inmaculada Gerrikagoitia Marina
- Irantzu Rico Barrio
- Nagore Puente Bustinza
- Jon Egaña Huguet
- Izaskun Elezgarai Gabantxo
- Pedro Rolando Grandes Moreno
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1
Universidad del País Vasco/Euskal Herriko Unibertsitatea
info
Universidad del País Vasco/Euskal Herriko Unibertsitatea
Lejona, España
- Olatz Arbelaitz Gallego (ed. lit.)
- Ainhoa Latatu (ed. lit.)
- Elixabete Pérez Gaztelu (ed. lit.)
Publisher: Udako Euskal Unibertsitatea, UEU = Universidad Vasca de Verano
ISBN: 978-84-8438-862-3, 978-84-8438-866-1
Year of publication: 2023
Pages: 159-166
Congress: Ikergazte. Nazioarteko Ikerketa Euskaraz (5. 2023. Donostia)
Type: Conference paper
Abstract
Temporal lobe epilepsy is the most common type of epilepsy in adults. Although available anticonvulsants reduce the excessive neuronl excitability, they are not always effective. Nowadays research focuses on the control of neuroinflammatory mechanisms switched on in epilepsy. Hence, non-neuronal brain cells and the endocannabinoid system have emerged as potential targets because the role of this system in neuroiriflammation mediated by cannabinoid receptor-expressing glial cells. We show changes in glial cells and the cannabinoid 1 (CBI) receptor, the main target of endogenous and exogenous cannabinoids, throughout brain regions in a mouse model of temporal lobe epilepsy. Remarkably, these anatomical changes impact on cognition (memory) and behavioral states (anxiety).