Level of IgG4 anti-desmoglein 3 antibodies correlates with disease activity in patients with pemphigus vulgaris

  1. Delgado García, José Antonio 1
  2. Pérez Robles, Carmen 1
  3. Mata Molanes, Juan José 1
  4. Moreno Narro, Laura 1
  5. Arana Berganza, Paula 1
  6. España Alonso, Agustín 1
  7. Moreno Parado, Cristina 1
  8. Merino Roncal, Juana 1
  9. Sánchez-Ibarrola, Alfonso 1
  1. 1 Clínica Universitaria de Navarra
    info

    Clínica Universitaria de Navarra

    Pamplona, España

    ROR https://ror.org/03phm3r45

Revista:
AUTOIMMUNE AND INFECTIOUS DISEASE

Año de publicación: 2015

Volumen: 1

Número: 1

Tipo: Artículo

GOOGLE SCHOLAR

Resumen

Results: The anti-desmoglein 3 specific immunoglobulin G1 and immunoglobulin G4 subclass study revealed that sera from patients with clinically inactive disease have lower anti-desmoglein 3 immunoglobulin G4 subclass antibody levels than sera from those with active disease by enzyme-linked immunosorbent assay (p=0.03). However, there was no statistically significant difference for immunoglobulin G1 between the two groups. Similarly, the presence of immunoglobulin G subclasses of anti-skin antibodies by indirect immunofluorescence between the two groups was not statistically significantly different.Conclusion: Levels of anti-desmoglein 3 immunoglobulin G4 subclass autoantibodies look very adequate to compare patients in remission with clinically active patients with pemphigus vulgaris (p=0.03