Fracción exhalada de óxido nítrico: validación de la medida con tiempo de espiración de 6 s con dos analizadores diferentes
- O. Sardón Prado
- E.G. Pérez-Yarza
- A. Aldasoro Ruiz
- J. Korta Murua
- J. Mintegui Aranburu
- J.I. Emparanza Knörr
ISSN: 1695-4033, 1696-4608
Year of publication: 2008
Volume: 69
Issue: 3
Pages: 221-226
Type: Article
More publications in: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP )
Abstract
Objective To validate the measurement of fractional exhaled nitric oxide concentration (FENO) using a 6-sec exhalation time in patients aged between 5 and 17 years with a stationary chemiluminescence analyser (NIOX®, Aerocrine) and a portable electrochemical analyser (NIOX-MINO®, Aerocrine). Material and methods FENO was assessed in 60 patients randomised into two groups. In Group 1 (n = 30, NIOX® analyser), three valid FENO measurements were obtained for two exhalation times (10 sec and 6 sec); the mean of the three measurements was recorded. In Group 2 (n = 30, NIOX-MINO®), a single valid measurement of FENO was obtained for each exhalation time. We analysed age, gender, weight, height, diagnosis, treatment, FENO and the number of attempts with both exhalation times in each analyser. Agreement between FENO assessed using 10-sec and 6-sec exhalations was assessed by Bland-Altman analysis and Cohen’s kappa. Results The mean (SD) age in Group 1 was 10.1 (3.07) years. The mean age in Group 2 was 10.43 (2.94) years. Bland-Altman analysis demonstrated good agreement between FENO values obtained with both exhalation times and with both de-vices. Cohen’s kappa, also demonstrated good agreement (NIOX®, K = 1; NIOX-MINO®, K = 0.93). Conclusions A 6-sec exhalation time is valid for measuring FENO with both analysers in children aged over 5 years.