ENFERMEDADES HEPÁTICAS
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Radboud University Nijmegen Medical Centre
Nimega, HolandaPublications en collaboration avec des chercheurs de Radboud University Nijmegen Medical Centre (15)
2024
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Stratified analyses refine association between TLR7 rare variants and severe COVID-19
Human Genetics and Genomics Advances, Vol. 5, Núm. 4
2023
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A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease
Science translational medicine, Vol. 15, Núm. 713, pp. eabq5930
2022
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Genetics, pathobiology and therapeutic opportunities of polycystic liver disease
Nature Reviews Gastroenterology and Hepatology, Vol. 19, Núm. 9, pp. 585-604
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Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models
Journal of Hepatology, Vol. 77, Núm. 1, pp. 177-190
2021
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Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease
United European Gastroenterology Journal, Vol. 9, Núm. 7, pp. 848-859
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Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models
Journal of Hepatology, Vol. 74, Núm. 2, pp. 394-406
2020
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Novel GANAB variants associated with polycystic liver disease
Orphanet Journal of Rare Diseases, Vol. 15, Núm. 1
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Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets
Liver International, Vol. 40, Núm. 7, pp. 1670-1685
2019
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Severity in polycystic liver disease is associated with aetiology and female gender: Results of the International PLD Registry
Liver International, Vol. 39, Núm. 3, pp. 575-582
2018
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Clinical management of polycystic liver disease
Journal of Hepatology, Vol. 68, Núm. 4, pp. 827-837
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MicroRNAs and extracellular vesicles in cholangiopathies
Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1864, Núm. 4, pp. 1293-1307
2017
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Fibrocystic Diseases of the Liver
Zakim and Boyer's Hepatology: A Textbook of Liver Disease (Elsevier), pp. 995-1014
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New Advances in Polycystic Liver Diseases
Seminars in Liver Disease
2016
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Ursodeoxycholic acid in advanced polycystic liver disease: A phase 2 multicenter randomized controlled trial
Journal of Hepatology, Vol. 65, Núm. 3, pp. 601-607
2015
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Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease
Journal of Hepatology, Vol. 63, Núm. 4, pp. 952-961